Thermo Fisher Scientific TWIST2 Polyclonal Antibody
TWIST2 단백질을 인식하는 Rabbit Polyclonal Antibody로, 인간·마우스·랫트 반응성. Western blot 및 IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제되어 높은 특이성 제공. 연구용으로 세포 내 핵 위치 TWIST2 검출에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide: KR FGR KRR YSK KSS Ed (corresponding to human TWIST2 protein, amino acids 27–41) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: SKBR3
- Cellular location: Nucleus
Target Information
TWIST2 binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A, and MEF2C.
It represses expression of proinflammatory cytokines such as TNFA and IL1B, and is involved in postnatal glycogen storage and energy metabolism.
TWIST2 also inhibits premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by altering internal signal transduction response to external growth factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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