Thermo Fisher Scientific Phospho-Paxillin (Tyr118) Polyclonal Antibody
Phospho-Paxillin (Tyr118) 특이적 폴리클로날 항체로 인간, 마우스, 랫트 반응성. Western blot에 적합하며 세포 부착 및 신호전달 연구에 활용. 항원 친화 크로마토그래피로 정제된 고순도 액상 형태. -20°C 보관, 연구용 전용.
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Thermo Fisher Scientific Phospho-Paxillin (Tyr118) Polyclonal Antibody
Applications
- Western Blot (WB): 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phospho-Paxillin (Tyr-118) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 118 from human paxillin. This sequence is highly conserved in rat and mouse paxillin and is also found in all isoforms (a, b, g) of paxillin. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942965 |
Product Specific Information
This antibody detects a 68 kDa protein corresponding to the molecular mass of paxillin on SDS-PAGE immunoblots of A431 cells treated with pervanadate. This reactivity is not observed after alkaline phosphatase treatment.
Target Information
Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with FAK and Crk through its SH2 domain, independent of the extracellular matrix. Although initially discovered in fibroblasts, paxillin phosphorylation may also be important during neurite extension and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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