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Thermo Fisher Scientific CD3e Chimeric Recombinant Rabbit Monoclonal Antibody (898H2-6-15)

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돼지 CD3e 단백질을 특이적으로 인식하는 Thermo Fisher Scientific의 키메릭 재조합 토끼 단클론 항체. WB, IHC, ICC/IF, Flow Cytometry 등 다양한 응용 가능. 고순도 Protein A 정제, 1 mg/mL 농도, 안정적 액상 형태로 연구용 적합.

브랜드: Thermo Fisher Scientific
카테고리: Monoclonal Antibodies
판매단위: pk

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Thermo Fisher Scientific MA551591 CD3e Chimeric Recombinant Rabbit Monoclonal Antibody (898H2-6-15) 200 ug pk판매 단위 pk

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Thermo Fisher Scientific · Thermo Fisher Scientific CD3e Chimeric Recombinant Rabbit Monoclonal Antibody (898H2-6-15)

Thermo Fisher Scientific CD3e Chimeric Recombinant Rabbit Monoclonal Antibody (898H2-6-15)

Applications and Tested Dilutions

Application	Tested Dilution
Western Blot (WB)	Assay-dependent
Immunohistochemistry (IHC)	Assay-dependent
Immunocytochemistry (ICC/IF)	10 µg/mL
Flow Cytometry (Flow)	1:100

Product Specifications

항목	내용
Species Reactivity	Pig
Host / Isotype	Rabbit / IgG, kappa
Expression System	HEK293 cells
Class	Recombinant Monoclonal
Type	Antibody
Clone	898H2-6-15
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Protein A
Storage Buffer	PBS
Contains	0.02% ProClin 300
Storage Conditions	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping Conditions	Wet ice

Immunogen

Murine antibodies were produced by immunising C3H/HeJ mice with swine peripheral blood lymphocytes. Hybridomas were generated by obtaining splenocytes from the immunised mice and fusing these with the non-Ig-producing myeloma cell line P3X63Ag8.653 via established methods.

Antigen Information:

Target Family: CD3
UniProt IDs: Q7YRN2-1, Q5PXD3-1, Q764N2-1, Q9XSJ9-1
Antigen Range: 1–196 (varies by isoform)
Antigen Length: 163–196 amino acids

Product Specific Information

Hybridoma 898H2-6-15 was shown via double-colour flow cytometry analysis to bind swine lymphocyte populations specifically. FACS analysis confirmed that purified 898H2-6-15 binds an epitope on CD3e shared by another anti-pig CD3 antibody (STH164).
CD3e is crucial for T cell receptor-dependent signal transduction across the lymphocyte membrane.

Target Information

The CD3 complex is essential for transducing antigen-recognition signals into T cell cytoplasm and regulating TCR surface expression. It consists of CD3 gamma, delta, epsilon, and zeta subunits, which are structurally related members of the immunoglobulin superfamily encoded on chromosome 11.
CD3 plays roles in TCR-induced growth arrest, cell survival, and proliferation. It is expressed on 68–82% of peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum, but not on B or NK cells.
Defects in CD3 genes are associated with CD3 immunodeficiency.