Thermo Fisher Scientific CD73 Recombinant Rabbit Monoclonal Antibody (JM11-40)

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:5,000
• Publications: -

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200
• Publications: -

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening of individual clones to select optimal candidates for production.
Advantages include:

• Superior specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to the larger rabbit immune repertoire

Target Information

CD73 (Ecto-5-prime-nucleotidase, 5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion of purine 5-prime mononucleotides to nucleosides at neutral pH, with AMP as the preferred substrate.
It forms a dimer of two identical 70 kDa subunits bound externally to the plasma membrane via a glycosyl phosphatidyl inositol linkage. CD73 serves as a marker of lymphocyte differentiation, and its deficiency is associated with various immunodeficiency diseases.
Defects in the CD73 gene can lead to joint and arterial calcification, and intestinal tuberculosis. Two transcript variants encoding different isoforms of CD73 have been identified.
The CD73 gene is localized to chromosome 6q14–q21.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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