Thermo Fisher Scientific Desmin (Muscle Cell Marker) Monoclonal Antibody (DES/4526)
Desmin 단백질을 표적하는 인간 근육세포 마커 항체. 다양한 근육 조직에서 특이적으로 발현되는 단백질 검출용. IHC(P), IHC(PFA) 등 면역조직화학 분석에 적합. 고순도 Protein A/G 정제, 보존제 무첨가.
- 카탈로그번호
- 1674-MSM6-P1ABX
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DES/4526 |
| Immunogen | Recombinant full-length human desmin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, being predominantly expressed in all types of muscle cells (cardiac, skeletal, and smooth muscle).
Regulation of desmin expression is stage and tissue-specific, induced during terminal skeletal muscle cell differentiation.
In skeletal and cardiac muscle cells, desmin is localized in the Z-disk region and at the intercalated disk.
Expression in smooth muscle is more heterogeneous.
Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, such as rhabdomyosarcomas and leiomyosarcomas.
During myocardial dysfunction, dramatic changes in desmin distribution have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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