Thermo Fisher Scientific Desmin (Muscle Cell Marker) Recombinant Mouse Monoclonal Antibody (rDES/1711)
Desmin 단백질을 표적으로 하는 재조합 마우스 단클론 항체로, 근육세포 표지자 연구에 적합합니다. IHC(P) 및 면역전기영동에 사용 가능하며, 다양한 종에 반응합니다. 단백질 A/G로 정제된 액상 형태로 4°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunoelectrophoresis (IE) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chicken, Hamster, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rDES/1711 |
| Immunogen | Recombinant full-length human desmin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Stability: Antibody is stable for 24 months.
- Positive Control: SJRH30 cells, uterus, or leiomyosarcoma.
- Cellular Localization: Cytoplasm
Specificity Comments:
Cytoskeletal intermediate filaments (IFs) are tissue-specific proteins used as markers to distinguish cell types and identify tumor origins. Desmin, a class III IF protein (469 amino acids) located near the Z line in sarcomeres, is expressed in adult differentiated muscle tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. The antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.
Target Information
Desmin (~53 kDa) shows high tissue specificity, being expressed predominantly in muscle cells (cardiac, skeletal, and smooth). Its expression is stage- and tissue-specific, induced during terminal differentiation of skeletal muscle cells. In skeletal and cardiac muscle, desmin localizes to the Z-disk and intercalated disk. Expression in smooth muscle is more heterogeneous. Coexpression of vimentin and desmin is observed in muscle-derived tumors such as rhabdomyosarcomas and leiomyosarcomas. Altered desmin distribution has been noted during myocardial dysfunction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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