Thermo Fisher Scientific Desmin (Muscle Cell Marker) Recombinant Mouse Monoclonal Antibody (rDES/1711)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Stability: Antibody is stable for 24 months.
• Positive Control: SJRH30 cells, uterus, or leiomyosarcoma.
• Cellular Localization: Cytoplasm

Specificity Comments:
Cytoskeletal intermediate filaments (IFs) are tissue-specific proteins used as markers to distinguish cell types and identify tumor origins. Desmin, a class III IF protein (469 amino acids) located near the Z line in sarcomeres, is expressed in adult differentiated muscle tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. The antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Target Information

Desmin (~53 kDa) shows high tissue specificity, being expressed predominantly in muscle cells (cardiac, skeletal, and smooth). Its expression is stage- and tissue-specific, induced during terminal differentiation of skeletal muscle cells. In skeletal and cardiac muscle, desmin localizes to the Z-disk and intercalated disk. Expression in smooth muscle is more heterogeneous. Coexpression of vimentin and desmin is observed in muscle-derived tumors such as rhabdomyosarcomas and leiomyosarcomas. Altered desmin distribution has been noted during myocardial dysfunction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.