Thermo Fisher Scientific Desmin Recombinant Rabbit Monoclonal Antibody (DES, 2960R)
Desmin 단백질을 표적으로 하는 재조합 토끼 단클론 항체. Western blot 및 파라핀 조직 IHC에 적합. 높은 특이성과 재현성을 제공하며 근육세포 관련 연구에 유용. PBS 용액 형태로 제공되며 방부제 무첨가.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chicken, Hamster, Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | DES, 2960R |
| Immunogen | Recombinant human full-length DES protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed):
Incubate antibody for 30 minutes at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, being predominantly expressed in all types of muscle cells (cardiac, skeletal, and smooth muscle).
Its expression is stage- and tissue-specific, induced during terminal skeletal muscle differentiation.
In skeletal and cardiac muscle cells, desmin localizes to the Z-disk region and intercalated disks, while in smooth muscle its expression is more heterogeneous.
Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue such as rhabdomyosarcomas and leiomyosarcomas.
During myocardial dysfunction, dramatic changes in desmin distribution have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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