Thermo Fisher Scientific Phospho-JAK2 (Tyr570) Polyclonal Antibody
JAK2 Tyr570 인산화 부위를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot 및 ICC/IF에 적합하며, 인산화된 JAK2의 내인성 수준 검출에 사용. PBS/glycerol buffer에 보관되며 -20°C에서 안정적.
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- PA5104705
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human JAK2 (Accession O60674), corresponding to amino acid residues around phosphorylated Tyr570. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816178 |
Product Specific Information
This antibody detects endogenous levels of JAK2 only when phosphorylated at Tyrosine 570.
Target Information
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in cytokine receptor signaling pathways and is mutated in polycythemia vera. It contains the catalytic domain (JH1) of JAK2. Activation of JAKs leads to phosphorylation of STAT proteins, which dimerize, translocate to the nucleus, and regulate transcription of interferon-stimulated genes. JAK2 is essential for IFN gamma-receptor complex initiation, while JAK1 acts as an amplifier. Mutations in JAK2 are associated with Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, and Acute myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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