Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (76-2-11), PE-Cyanine5

Applications

• Flow Cytometry (Flow): Tested dilution 0.2 µg/10^6 cells

Product Specifications

Additional Formats

• Unconjugated
• APC
• Biotin
• FITC
• PE
• Request custom conjugation

Target Information

Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules. Its counterpart, CD4, acts as a co-receptor for MHC class II molecules. CD8 also exists as a disulfide-linked homodimer of CD8α on subsets of T cells, NK cells, monocytes, and dendritic cells. Engagement of MHC-I/peptide complexes triggers recruitment of Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are crucial for pathogen and tumor cell clearance, and differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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