Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (76-2-11), FITC

Applications

Flow Cytometry (Flow)

• Tested Dilution: 1 µg/10⁶ cells

Product Specifications

Available Formats

• Unconjugated (Cat. No. MA5-28717)
• APC (Cat. No. MA5-28712)
• Biotin (Cat. No. MA5-28713)
• PE (Cat. No. MA5-28715)
• PE-Cyanine5 (Cat. No. MA5-28716)
• Custom conjugation available upon request

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family that plays a key role in T cell signal transduction, differentiation, and activation.
CD8 is primarily expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules.
The CD8α chain is essential for MHC-I binding and is also expressed as a homodimer on subsets of T cells, NK cells, monocytes, and dendritic cells.
Engagement of MHC-I/peptide complexes triggers Lck kinase recruitment, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs are critical for pathogen and tumor cell clearance, with differentiation enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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