Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (76-2-11), FITC
돼지 CD8α 항원을 인식하는 마우스 단클론 항체로, FITC로 표지되어 유세포분석(Flow Cytometry)에 적합합니다. 498/517 nm의 여기/방출 특성을 가지며, PBS(pH 7.4)에 보관됩니다. 4°C 암소 보관, 연구용으로만 사용 가능합니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1 µg/10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Pig |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 76-2-11 |
| Immunogen | Fresh dd miniature swine thymocytes |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.4 |
| Contains | <0.1% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745673 |
Available Formats
- Unconjugated (Cat. No. MA5-28717)
- APC (Cat. No. MA5-28712)
- Biotin (Cat. No. MA5-28713)
- PE (Cat. No. MA5-28715)
- PE-Cyanine5 (Cat. No. MA5-28716)
- Custom conjugation available upon request
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family that plays a key role in T cell signal transduction, differentiation, and activation.
CD8 is primarily expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules.
The CD8α chain is essential for MHC-I binding and is also expressed as a homodimer on subsets of T cells, NK cells, monocytes, and dendritic cells.
Engagement of MHC-I/peptide complexes triggers Lck kinase recruitment, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs are critical for pathogen and tumor cell clearance, with differentiation enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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