Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (76-2-11), PE

Applications

• Flow Cytometry (Flow): 0.2 µg/10^6 cells

Product Specifications

Additional Formats

• Unconjugated (MA5-28717)
• APC (MA5-28712)
• Biotin (MA5-28713)
• FITC (MA5-28714)
• PE-Cyanine5 (MA5-28716)
• Custom conjugation available upon request

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family, essential in signal transduction and T cell differentiation and activation. CD8 is mainly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules, while CD4 serves as the co-receptor for MHC class II.
CD8α is critical for MHC-I binding and is also found as a homodimer on subsets of T cells, NK cells, monocytes, and dendritic cells. Interaction with MHC-I/peptide complexes on antigen-presenting cells recruits the kinase Lck, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs play a key role in eliminating pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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