Thermo Fisher Scientific MCAM (Melanoma Cell Adhesion Molecule)/MUC18/CD146 Monoclonal Antibody (MUC18/1130)
CD146(MCAM/MUC18) 단백질을 표적으로 하는 Mouse 모노클로날 항체. 인간 시료에 반응하며 IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합. 단백질 A/G로 정제된 액상형 항체로, 보존제가 없으며 -20°C에서 보관.
- 카탈로그번호
- 4162-MSM4-P1ABX
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific MCAM (Melanoma Cell Adhesion Molecule)/MUC18/CD146 Monoclonal Antibody (MUC18/1130)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MUC18/1130 |
| Immunogen | Recombinant full-length human MUC18 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. It is expressed at cell-cell junctions in endothelial cells and also in various normal and malignant cells. CD146 functions as a calcium-independent cell adhesion molecule and may act in signal transduction by recruiting Fyn kinase, leading to tyrosine phosphorylation of intracellular proteins involved in actin cytoskeleton assembly. It plays a role in maintaining endothelial cohesion and may facilitate melanoma cell interaction with vascular elements, enhancing tumor spread. CD146 is also active in neural crest cells during embryonic development and acts as a surface receptor triggering tyrosine phosphorylation of FYN and PTK2, with transient intracellular calcium increase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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