Thermo Fisher Scientific MCAM (Melanoma Cell Adhesion Molecule)/MUC18/CD146 Monoclonal Antibody (C146/634)
인간 CD146(MCAM/MUC18)을 인식하는 마우스 단클론 항체로, IHC, ICC/IF, Flow Cytometry에 적합합니다. 비결합형 액상 형태이며, 4°C에서 보관합니다. 세포 부착 및 신호전달 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C146/634 |
| Immunogen | Recombinant human CD146 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. It is expressed at cell-cell junctions in endothelial cells and in various normal and malignant cell types. CD146 functions as a calcium-independent cell adhesion molecule and may also serve as a signal transduction molecule, recruiting Fyn kinase and promoting tyrosine phosphorylation of proteins involved in actin cytoskeleton assembly.
CD146 contributes to endothelial cell adhesion and cohesion at intercellular junctions in vascular tissue. Its expression may facilitate melanoma cell interaction with vascular elements, enhancing tumor spread. Additionally, CD146 may act as an adhesion molecule in neural crest cells during embryonic development and as a surface receptor triggering tyrosine phosphorylation of FYN and PTK2, leading to transient intracellular calcium increases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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