Thermo Fisher Scientific FOS Monoclonal Antibody (OTI5A11), TrueMAB

Applications

• Western Blot (WB): 1:200–1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, an additional desalting step is recommended (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

FBJ murine osteosarcoma viral oncogene homolog, also known as Cellular proto-oncogene Fos (c-Fos), belongs to the Fos transcription factor family and is encoded by the C-FOS gene on chromosome 14.
c-Fos forms a heterodimer with c-Jun to create the Activator Protein-1 (AP-1) transcription factor, which regulates transcription of genes involved in cellular signal transduction, proliferation, and differentiation.
It is phosphorylated by various stimuli, including growth factors and insulin, at multiple sites. The kinase ERK MAPK phosphorylates c-Fos at Threonine 232, influencing its nuclear localization and transcriptional activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.