Thermo Fisher Scientific MBP Polyclonal Antibody
MBP 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. Antigen affinity chromatography로 정제된 고순도 항체. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:10–1:500 | 1 publication |
| ELISA | 1:100–1:2,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Residues 49–62 of human, mouse, and rat MBP protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2140360 |
Product Specific Information
The PA1-46447 immunogen corresponds to residues 49–62 of Isoforms 5 and 6 of the human MBP protein.
It also corresponds to Isoform 1 between amino acids 182–195 of the 33 kDa isoform.
This antibody detects mouse and rat MBP protein as well.
Suggested positive control: normal human brain lysate.
Target Information
The MBP (Myelin Basic Protein) gene encodes a major constituent of the myelin sheath in oligodendrocytes and Schwann cells of the nervous system. MBP-related transcripts are also expressed in bone marrow and the immune system.
These transcripts originate from the long MBP gene (also known as Golli-MBP), which includes three additional exons upstream of the classic MBP exons.
Alternative splicing of Golli and MBP transcription start sites produces two sets of MBP-related transcripts and gene products:
- Golli-MBP transcripts contain unique exons spliced in-frame with MBP exons, encoding hybrid proteins with N-terminal Golli and MBP sequences.
- Classic MBP transcripts contain only MBP exons and encode the well-characterized myelin basic proteins.
This complex gene structure is conserved among species, suggesting its importance in gene regulation and function.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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