Thermo Fisher Scientific Phospho-TPH1 (Ser58) Polyclonal Antibody
Phospho-TPH1 (Ser58) 폴리클로날 항체로, Western blot에서 인산화된 Tryptophan Hydroxylase 단백질 검출에 적합합니다. Rabbit IgG 기반, 다양한 종에 반응하며, 고순도 친화 크로마토그래피 정제 제품입니다. 연구용 전용.
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rabbit, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser58 of rat TPH1 conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_561857 |
Product Specific Information
This antibody is predicted to react with bovine, chicken, human, mouse, non-human primate, Xenopus, rat, and zebrafish based on 100% sequence homology.
It is specific for the ~55 kDa Tryptophan Hydroxylase protein phosphorylated at Ser58 in Western blots of human dorsal Raphe nucleus.
Target Information
Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, the first step in the biosynthesis of indoleamines such as serotonin and melatonin.
In mammals:
- Serotonin biosynthesis occurs predominantly in neurons originating in the Raphe nuclei of the brain.
- Melatonin synthesis takes place within the pineal gland.
TPH activity is rate-limiting for serotonin but not for melatonin biosynthesis.
Serotonin acts mainly as a neurotransmitter, while melatonin is the principal hormone secreted by the pineal gland.
TPH activity is enhanced by phosphorylation via cAMP-dependent protein kinase (PKA) and Ca²⁺/calmodulin kinase II (CAM K II).
Both PKA and CAM K II phosphorylate Ser58 within the regulatory domain of TPH.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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