Thermo Fisher Scientific LRRK2 Polyclonal Antibody
LRRK2 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot에 적합합니다. 인간 LRRK2의 특정 펩타이드 서열을 면역원으로 사용하였으며, 파킨슨병 연구에 유용합니다. 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
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Applications and Tested Dilution
- Western Blot (WB): 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues N(2506)LEKHIEVRKELAEKMR(2522) of human LRRK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_1958304 |
Product Specific Information
- The target sequence has 88% sequence homology with mouse and rat.
- Suggested positive control: human brain lysate.
Target Information
LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in LRRK2 have been associated with Parkinson’s disease. LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankyrin repeat region, a leucine-rich repeat domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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