Thermo Fisher Scientific C17orf37 Monoclonal Antibody (OTI2D5), TrueMAB
C17orf37 단백질을 인식하는 Mouse 단일클론 항체로, WB, IHC, ICC/IF에 사용 가능. 인간 시료 반응성, Lyophilized 형태로 제공되며, 연구용으로 적합. ERBB2 관련 종양 표지자 연구에 유용.
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Thermo Fisher Scientific C17orf37 Monoclonal Antibody (OTI2D5), TrueMAB
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D5 |
| Immunogen | Full length human recombinant protein of human C17orf37 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to achieve approximately 1 mg/mL antibody concentration.
- For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
C35 (C17orf37) is a novel tumor biomarker abundantly expressed in breast cancer. It is located on chromosome 17q12, 505 nucleotides from the 3′ end of the ERBB2 (HER2/neu) oncogene, which is targeted by trastuzumab (Herceptin). The genes encoding C35 and ERBB2 are arranged tail-to-tail. The ORF37 open reading frame encodes a 12 kDa protein of unknown function.
The ERBB2 oncogene is an important predictor of patient outcome and response to therapy in breast cancer. Identification of shared tumor-specific targets like C35 is useful for developing broadly applicable therapeutic strategies.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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