Thermo Fisher Scientific C17orf37 Monoclonal Antibody (OTI2D5), TrueMAB

Thermo Fisher Scientific C17orf37 Monoclonal Antibody (OTI2D5), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• For reconstitution, add 100 µL distilled water to achieve approximately 1 mg/mL antibody concentration.
• For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

C35 (C17orf37) is a novel tumor biomarker abundantly expressed in breast cancer. It is located on chromosome 17q12, 505 nucleotides from the 3′ end of the ERBB2 (HER2/neu) oncogene, which is targeted by trastuzumab (Herceptin). The genes encoding C35 and ERBB2 are arranged tail-to-tail. The ORF37 open reading frame encodes a 12 kDa protein of unknown function.
The ERBB2 oncogene is an important predictor of patient outcome and response to therapy in breast cancer. Identification of shared tumor-specific targets like C35 is useful for developing broadly applicable therapeutic strategies.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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