Thermo Fisher Scientific COX2 Monoclonal Antibody (COX 229)
COX2 단일클론 항체(COX 229)는 인간 및 마우스에서 반응하며, Western blot, IHC, ICC/IF 등 다양한 응용에 적합합니다. 단백질 A로 정제된 액상 항체로, COX-2 단백질 검출에 특화되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 12 publications |
| Immunohistochemistry (IHC) | Assay-dependent | View 11 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 12 publications |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | View 3 publications |
| ELISA | Assay-dependent | View publications |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | COX 229 |
| Immunogen | Synthetic peptide from human COX-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533224 |
Target Information
COX2 converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis, including production of inflammatory prostaglandins.
The conversion of arachidonate to prostaglandin H2 involves two reactions:
- A cyclooxygenase (COX) reaction converting arachidonate to prostaglandin G2 (PGG2).
- A peroxidase reaction reducing PGG2 to prostaglandin H2 (PGH2).
COX2 is constitutively expressed in certain tissues such as endothelium, kidney, and brain, and is up-regulated under pathological conditions like cancer and inflammation.
Up-regulation of COX2 is associated with increased cell adhesion, phenotypic changes, resistance to apoptosis, and tumor angiogenesis.
In cancer cells, COX2 is a key enzyme in the production of prostaglandin E2 (PGE2), which modulates motility, proliferation, and resistance to apoptosis.
COX2 is naturally inhibited by calcitriol (active Vitamin D) and is a known target of NSAIDs such as aspirin, reducing pain and inflammation caused by COX2 activity.
Glucocorticoids can chronically repress PTGS2 gene activity by interfering with transcription initiation and elongation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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