Thermo Fisher Scientific c-Myc Oncoprotein Monoclonal Antibody (MYC699)
c-Myc 단백질을 인식하는 mouse monoclonal antibody로, 인간 및 영장류 시료에 반응합니다. ICC/IF, Flow Cytometry, ELISA에 사용 가능하며, Protein A/G로 정제된 액상 형태입니다. 종특이성이 높고, 연구용으로 적합합니다.
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- 4609-MSM1-P1ABX
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| ELISA | 2–4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chimpanzee, Human, Non-human primate |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MYC699 |
| Immunogen | Synthetic peptide corresponding to aa 408–439 (AEEQKLISEEDLLRKRREQLKHKLEQL-RNSCA) from the C-terminus of human c-Myc, coupled to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Mouse
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is activated in various tumor cells and plays essential roles in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is associated with cell proliferation and regulation.
c-Myc is crucial for vasculogenesis and angiogenesis during tumor development.
The c-Myc oncogene (p62 c-Myc) regulates normal cellular proliferation and differentiation, while deregulated expression induces apoptosis in multiple cell types.
Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags at either amino- or carboxy-termini.
Amplification or translocation of the c-Myc gene is implicated in several human cancers, including lung, breast, and colon carcinomas, as well as Burkitt’s lymphoma and other B-cell proliferative disorders.
Aberrant c-Myc expression has been observed in tumors of colorectal, gastric, hepatic, mammary, ovarian, pulmonary, and hematopoietic origins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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