Thermo Fisher Scientific c-Myc Oncoprotein Monoclonal Antibody (MYC699)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Does not react with Mouse

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is activated in various tumor cells and plays essential roles in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is associated with cell proliferation and regulation.
c-Myc is crucial for vasculogenesis and angiogenesis during tumor development.
The c-Myc oncogene (p62 c-Myc) regulates normal cellular proliferation and differentiation, while deregulated expression induces apoptosis in multiple cell types.
Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags at either amino- or carboxy-termini.
Amplification or translocation of the c-Myc gene is implicated in several human cancers, including lung, breast, and colon carcinomas, as well as Burkitt’s lymphoma and other B-cell proliferative disorders.
Aberrant c-Myc expression has been observed in tumors of colorectal, gastric, hepatic, mammary, ovarian, pulmonary, and hematopoietic origins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.