Thermo Fisher Scientific c-Myc Oncoprotein Monoclonal Antibody (CT14.G4)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1–2 µg/mL

Flow Cytometry (Flow)

• Tested Dilution: 1–2 µg/10⁶ cells

Product Specifications

Product Specific Information

• Does not react with Mouse

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a crucial role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.

Phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK is functionally associated with cell proliferation and regulation.
Studies indicate that c-Myc is essential for vasculogenesis and angiogenesis in tumor development.

The c-myc oncogene (p62 c-myc) regulates normal cellular proliferation and differentiation; its deregulated expression can induce apoptosis.
Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to amino or carboxy termini of target proteins.

c-Myc-, N-Myc-, and L-Myc-encoded proteins are involved in cell proliferation, differentiation, and neoplastic disease.
Amplification of the c-Myc gene has been found in lung, breast, and colon carcinomas, while N-Myc amplification is common in neuroblastomas.

Translocation of the c-myc locus on chromosome 8 to immunoglobulin loci on chromosomes 14, 2, or 22 is characteristic of Burkitt’s lymphoma and other B-cell lymphoproliferative conditions.
Aberrant c-Myc expression occurs in tumors of colorectal, gastric, hepatic, mammary, ovarian, pulmonary, and hematopoietic origins, among others.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.