Thermo Fisher Scientific c-Myc Oncoprotein Monoclonal Antibody (CT14.G4)
Thermo Fisher Scientific의 c-Myc Oncoprotein Monoclonal Antibody (CT14.G4)는 인간 및 영장류 시료에 반응하는 마우스 IgG1 항체입니다. ICC/IF 및 Flow Cytometry에 적합하며, c-Myc 단백질 연구에 사용됩니다. 단백질 A/G로 정제된 액상 항체로, 4°C에서 보관합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1–2 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 1–2 µg/10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chimpanzee, Human, Non-human primate |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CT14.G4 |
| Immunogen | A synthetic peptide corresponding to aa 408–439 (AEEQKLISEEDLLRKRREQLKHKLEQL-RNSCA) from C-terminus of human c-myc, coupled to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Mouse
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays critical roles in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2, and JNK has been associated with cell proliferation and regulation.
Studies indicate that c-Myc is essential for vasculogenesis and angiogenesis in tumor development. Deregulated expression of c-Myc induces apoptosis and contributes to oncogenesis in multiple tissue types.
Amplification or translocation of the c-Myc gene is linked to several human cancers, including lung, breast, colon carcinomas, and Burkitt’s lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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