Thermo Fisher Scientific c-Myc Oncoprotein Monoclonal Antibody (MYC699)
Thermo Fisher의 c-Myc 단클론 항체(MYC699)는 인간 및 영장류 시료에서 c-Myc 단백질을 검출하는 데 사용됩니다. ICC/IF, Flow Cytometry, ELISA에 적합하며, Protein A/G로 정제된 액상 형태입니다. 4°C에서 보관하며 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| ELISA | 2–4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chimpanzee, Human, Non-human primate |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MYC699 |
| Immunogen | Synthetic peptide corresponding to aa 408–439 (AEEQKLISEEDLLRKRREQLKHKLEQL-RNSCA) from the C-terminus of human c-Myc, coupled to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Mouse.
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in tumor cells and regulates cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is associated with cell proliferation control.
c-Myc plays a key role in vasculogenesis and angiogenesis during tumor development. Deregulated c-Myc expression can induce apoptosis and is implicated in various cancers including lung, breast, and colon carcinoma, as well as Burkitt’s lymphoma.
Antibodies against c-Myc epitopes can recognize Myc-tagged fusion proteins. Amplification or translocation of the c-Myc gene is observed in multiple tumor types and hematopoietic neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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