Thermo Fisher Scientific IRE1A Polyclonal Antibody, Biotin
IRE1A 단백질을 표적으로 하는 Biotin 결합 폴리클로날 항체입니다. Western blot, IHC, ELISA, IP 등 다양한 응용에 적합합니다. 인간, 생쥐, 랫트 반응성이 있으며, 고순도 Affinity chromatography로 정제되었습니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- IRE1A-Y-BIOTIN
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific IRE1A Polyclonal Antibody, Biotin
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Chicken / IgY |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acid region 900–1000 of human IRE1A protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ERN1 (Endoplasmic Reticulum to Nucleus Signaling 1) is a human homologue of the yeast Ire1 gene product possessing intrinsic kinase and endoribonuclease activities. It plays a key role in ER-based stress signaling by sensing unfolded proteins and transmitting signals to the nucleus through XBP1 mRNA splicing. ERN1 is essential for extraembryonic cell function and fetal viability. Under stress conditions that lead to unfolded protein accumulation, depletion of IRE1 induces apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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