Thermo Fisher Scientific IRE1 Polyclonal Antibody, Biotin
IRE1 단백질을 인식하는 Biotin 결합 폴리클로날 항체로, Western blot, ELISA, IP 등 다양한 응용에 적합. 인간, 마우스, 랫트에서 반응하며 고순도 Affinity chromatography로 정제됨. ER 스트레스 신호 연구용으로 이상적.
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Thermo Fisher Scientific IRE1 Polyclonal Antibody, Biotin
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to unique amino acid sequence within amino acid region 900–1000 on human IRE1A protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ERN1 serine/threonine kinase, also known as endoplasmic reticulum to nucleus signaling 1 (IRE1), is a human homologue of the yeast Ire1 gene product. It possesses intrinsic kinase and endoribonuclease activities and plays a key role in ER-based stress signaling. ERN1 regulates IRE1 proteolysis in mammalian cells and is essential for fetal viability due to its function in extraembryonic cells.
IRE1 acts as a sensor of unfolded proteins in the ER, transmitting stress signals to the nucleus by splicing XBP1 mRNA into a potent transcriptional activator of the unfolded protein response. Null mutants remain viable under normal conditions but are nonviable under ER stress. Expression of a dominant negative form of IRE1p leads to apoptosis when unfolded proteins accumulate in the ER.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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