Thermo Fisher Scientific DIABLO Monoclonal Antibody (78-1-118)
DIABLO 단백질을 인식하는 Mouse monoclonal 항체로 Western blot, ICC/IF, IP에 적합. Human, Mouse, Rat 반응성. 비결합(Unconjugated) 액상 형태로 제공되며, 세포자멸사(apoptosis) 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
| Immunoprecipitation (IP) | 1:10–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, IgG3 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 78-1-118 |
| Immunogen | Recombinant mature human Smac/DIABLO (lacks amino acids 1–55 present in Smac/DIABLO precursor) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_568516 |
Product Specific Information
Suggested positive control: 293 whole cell lysate.
Target Information
DIABLO (Smac) is a mitochondrial protein involved in activating apoptosis by neutralizing inhibitors of apoptosis (IAP) family proteins. During apoptosis, Smac exits the mitochondria and enters the cytosol, playing a crucial role in regulating cell death pathways. Mitochondrial-mediated apoptosis is essential for development and tissue homeostasis, and its dysregulation can lead to malignant disorders. Smac/DIABLO also contributes to sensitizing cancer cells to immune- or drug-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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