Thermo Fisher Scientific Phospho-GCN2 (Thr899) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:3,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human EIF2AK4(Accession Q9P2K8), corresponding to amino acid residues around phosphorylated Thr899. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:GCN2,uniProtId:Q9P2K8-1,ncbiNodeId:9606,antigenRange:899,antigenLength:1649,antigenImageFileName:PA5-105886_GCN2_Q9P2K8-1_Rabbit.svg,antigenImageFileNamePDP:PA5-105886_GCN2_Q9P2K8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2817285

Product Specific Information

Antibody detects endogenous levels of GCN2 only when phosphorylated at Thr899.

Target Information

EIF2AK4 (GCN2) is a metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor-2 in response to low amino acid availability. It plays a role as an activator of the integrated stress response required for adapatation to amino acid starvation. Mutations in the gene lead to pulmonary vennocclusive disease 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.