Thermo Fisher Scientific Protein Tyrosine Phosphatase, non-receptor type 6 Monoclonal Antibody (PTPN6/7544)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

• Positive Control: Human tonsil, lymph node, or spleen
• Cellular Location: Cytoplasm, Nucleus
  In neurons, translocates into the nucleus after treatment with angiotensin II.

Target Information

SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase primarily expressed in hematopoietic cells.
It contains two SH2 domains, a catalytic domain, and a regulatory domain.
SHP-1 removes phosphates from target proteins, thereby downregulating several tyrosine kinase-regulated pathways.
In hematopoietic cells, SHP-1 binds to phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth.
Overexpression in epithelial cells leads to dephosphorylation of the Ros receptor tyrosine kinase, reducing Ros-dependent proliferation.
In myeloid cells, SHP-1 associates with the IL-3R beta chain to downregulate IL-3-induced phosphorylation and proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.