Thermo Fisher Scientific Protein Tyrosine Phosphatase, non-receptor type 6 Monoclonal Antibody (CPTC-PTPN6-2)
인간 SHP-1(PTPN6)을 인식하는 마우스 단클론 항체. Western blot에 최적화되어 있으며, 단백질 A/G로 정제된 액상 형태. PBS(pH 7.4)에 보존제 없이 제공되며, -20°C 이하에서 보관 권장. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1–2 µg/mL
- Antibody is tested in direct ELISA.
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CPTC-PTPN6-2 |
| Immunogen | Recombinant human full-length PTPN6 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C or -80°C if preferred |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase expressed primarily in hematopoietic cells. It consists of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate tyrosine kinase-regulated pathways. In hematopoietic cells, SHP-1 binds to phosphorylated erythropoietin receptors (EpoR) to negatively regulate growth. Overexpression in epithelial cells leads to dephosphorylation of the Ros receptor tyrosine kinase, reducing Ros-dependent proliferation. In myeloid cells, SHP-1 associates with the IL-3R beta chain to downregulate IL-3-induced phosphorylation and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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