Thermo Fisher Scientific Protein Tyrosine Phosphatase, non-receptor type 6 Monoclonal Antibody (CPTC-PTPN6-2)

Applications

• Western Blot (WB): 1–2 µg/mL
• Antibody is tested in direct ELISA.

Product Specifications

Target Information

SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase expressed primarily in hematopoietic cells. It consists of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate tyrosine kinase-regulated pathways. In hematopoietic cells, SHP-1 binds to phosphorylated erythropoietin receptors (EpoR) to negatively regulate growth. Overexpression in epithelial cells leads to dephosphorylation of the Ros receptor tyrosine kinase, reducing Ros-dependent proliferation. In myeloid cells, SHP-1 associates with the IL-3R beta chain to downregulate IL-3-induced phosphorylation and proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.