Thermo Fisher Scientific SLAMF7/CS1/CD319 Monoclonal Antibody (SLAMF7, 3649)
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인간 SLAMF7 단백질을 인식하는 Mouse IgG1 단일클론 항체. IHC(P) 검증 완료. 단백질 A/G 정제, PBS(pH 7.4) 용액 형태, 보존제 없음. -20°C 또는 -80°C 보관, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SLAMF7, 3649 |
| Immunogen | Recombinant fragment of human SLAMF7 protein (around aa 249–335) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA-fixed): Incubate antibody for 30 minutes at room temperature.
- For formalin-fixed tissues, heat sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, then cool at room temperature for 20 minutes.
Target Information
SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain.
- Isoform 1 mediates NK cell activation through a SAP-independent, ERK-mediated pathway and may play a role in lymphocyte adhesion.
- Isoform 3 does not mediate activation.
- SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro).
- Expression detected in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung, and trachea.
- Expressed in NK cells, activated B-cells, NK-cell lines but not in promyelocytic, B-, or T-cell lines.
- Isoform 3 is expressed at a much lower level than isoform 1.
- There are three named isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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