Thermo Fisher Scientific Protein Tyrosine Phosphatase, non-receptor type 6 Monoclonal Antibody (PTPN6/7543)
인간 PTPN6(SHP-1)을 인식하는 단일클론 항체로, IHC(P)에서 1–2 µg/mL 농도로 사용 가능. 단백질 A/G로 정제된 액상 항체이며, 4°C에서 보관. 세포질 및 핵에 위치한 SHP-1 단백질 검출에 적합. 연구용으로만 사용.
- 카탈로그번호
- 5777-MSM3-Px (2개 옵션)
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PTPN6/7543 |
| Immunogen | Recombinant fragment (around aa395–595) of human PTPN6 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human tonsil, lymph node, or spleen
- Cellular Location: Cytoplasm, nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II.
Target Information
SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase expressed primarily in hematopoietic cells. It consists of two SH2 domains, a tyrosine phosphatase catalytic domain, and a C-terminal regulatory domain. SHP-1 dephosphorylates target proteins to downregulate tyrosine kinase-regulated pathways.
In hematopoietic cells, SHP-1 binds tyrosine-phosphorylated EpoR to negatively regulate hematopoietic growth. Overexpression in epithelial cells leads to dephosphorylation of the Ros receptor tyrosine kinase, suppressing Ros-dependent cell proliferation. In myeloid cells, SHP-1 associates with the IL-3R beta chain to downregulate IL-3-induced phosphorylation and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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