Thermo Fisher Scientific Protein Tyrosine Phosphatase, non-receptor type 6 Monoclonal Antibody (PTPN6/7543)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

• Positive Control: Human tonsil, lymph node, or spleen
• Cellular Location: Cytoplasm, nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II.

Target Information

SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase expressed primarily in hematopoietic cells. It consists of two SH2 domains, a tyrosine phosphatase catalytic domain, and a C-terminal regulatory domain. SHP-1 dephosphorylates target proteins to downregulate tyrosine kinase-regulated pathways.
In hematopoietic cells, SHP-1 binds tyrosine-phosphorylated EpoR to negatively regulate hematopoietic growth. Overexpression in epithelial cells leads to dephosphorylation of the Ros receptor tyrosine kinase, suppressing Ros-dependent cell proliferation. In myeloid cells, SHP-1 associates with the IL-3R beta chain to downregulate IL-3-induced phosphorylation and proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.