Thermo Fisher Scientific CEP164 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CEP164 protein. Validated for WB and IHC applications. High purity (>95%) via antigen affinity chromatography. Suitable for research on centrosomal and cilia formation proteins. For research use only.
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Thermo Fisher Scientific CEP164 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein of human CEP164 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720188 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
CEP164 was initially identified as a centrosomal protein but is also involved in the formation of primary cilia, the microtubule-based sensory antennae projecting from many eukaryotic cells. It plays a role in the DNA damage response as a mediator protein interacting with ATR and ATM, which trigger cellular responses including DNA damage-induced cell cycle checkpoints. CEP164 is phosphorylated upon replication stress, UV radiation, and ionizing radiation. Silencing of CEP164 reduces DNA damage-induced phosphorylation of several proteins in the signaling cascade and compromises cell survival after UV damage. At least two isoforms of CEP164 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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