Thermo Fisher Scientific CD148 Monoclonal Antibody (MEM-CD148/05), Biotin
CD148 단백질을 인식하는 Biotin 결합 마우스 단클론 항체. 인간 시료에 반응하며, 유세포분석(Flow Cytometry)에 적합. 고순도의 Size-exclusion chromatography로 정제. PBS 완충액에 15mM sodium azide 포함, 4°C 보관.
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Applications
- Flow Cytometry (Flow): 1–12 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-CD148/05 |
| Immunogen | Human recombinant CD148 (amino acids 1–444) |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage conditions | 4°C, do not freeze |
| RRID | AB_2745550 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular epitope of CD148, a highly glycosylated (up to 250 kDa) receptor-like protein tyrosine phosphatase expressed mainly in lymphocytes, myeloid cells, and epithelial cells.
Target Information
CD148 is a highly glycosylated transmembrane protein (up to 250 kDa) containing eight fibronectin type III domains in the extracellular region and one tyrosine phosphatase domain in the cytoplasmic region. Expression is found broadly on fibroblasts, epithelial cells, lymphocytes (B, T, and NK cells), and myeloid cells (monocytes and granulocytes). CD148 can dephosphorylate proteins such as LAT and PLC-gamma and is involved in the downregulation of T cell activation. Conversely, CD148 expression can be upregulated following T cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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