Thermo Fisher Scientific Phospho-c-Myc (Thr58, Ser62) Recombinant Rabbit Monoclonal Antibody (SZ02-06)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select optimal candidates.
Key advantages include:

• Improved specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broad immunoreactivity due to the rabbit immune repertoire

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in tumor cells and plays critical roles in cell proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK regulates c-Myc function in proliferation and cycle control.
c-Myc is essential for vasculogenesis and angiogenesis during tumor development. Deregulated c-Myc expression can induce apoptosis in various cell types.

Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to either amino- or carboxy-termini.
Amplification of the c-Myc gene is found in several human cancers including lung, breast, and colon carcinomas.
Translocation of the c-Myc locus on chromosome 8 to immunoglobulin loci on chromosomes 14, 2, or 22 is characteristic of Burkitt’s lymphoma and other B-cell proliferative disorders.
Aberrant expression of c-Myc is also observed in tumors of colorectal, gastric, hepatic, mammary, ovarian, pulmonary, and hematopoietic origin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.