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Thermo Fisher Scientific CD49f (Integrin alpha 6) Monoclonal Antibody (eBioGoH3 (GoH3)), Biotin, eBioscience
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Thermo Fisher Scientific CD49f (Integrin alpha 6) Monoclonal Antibody (eBioGoH3 (GoH3)), Biotin, eBioscience

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CD49f (Integrin alpha 6) 단클론 항체로 인간 및 마우스 세포에서 교차 반응성을 보입니다. Flow cytometry와 IHC(Frozen)에 적합하며, Biotin으로 표지되어 있습니다. 세포 부착 및 신호전달 연구에 활용 가능하며, 0.5 mg/mL 농도로 액상 형태로 제공됩니다.

카탈로그번호
13-0495-8x (2개 옵션)
판매단위
pk
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2개 옵션
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마지막 업데이트 2025. 08. 04. 오후 07:01
Thermo Fisher Scientific 13-0495-82 CD49f (Integrin alpha 6) Monoclonal Antibody (eBioGoH3 (GoH3)), Biotin, eBioscience 100 ug pk판매 단위 pk ·
재고 확인 필요
384,200원VAT 포함 422,620원
Thermo Fisher Scientific 13-0495-80 CD49f (Integrin alpha 6) Monoclonal Antibody (eBioGoH3 (GoH3)), Biotin, eBioscience 25 ug pk판매 단위 pk ·
재고 확인 필요
180,600원VAT 포함 198,660원

Thermo Fisher Scientific · Thermo Fisher Scientific CD49f (Integrin alpha 6) Monoclonal Antibody (eBioGoH3 (GoH3)), Biotin, eBioscience

Thermo Fisher Scientific CD49f (Integrin alpha 6) Monoclonal Antibody (eBioGoH3 (GoH3)), Biotin, eBioscience

Applications and Tested Dilutions

Application Tested Dilution Publications
Western Blot (WB) - View 1 publication
Immunohistochemistry (IHC) - View 4 publications
Immunohistochemistry (Frozen) (IHC (F)) Assay-Dependent -
Immunocytochemistry (ICC/IF) - View 1 publication
Flow Cytometry (Flow) 0.25 µg/test View 43 publications
Neutralization (Neu) - View 2 publications

Product Specifications

항목 내용
Published Species Human, Mouse
Host / Isotype Rat / IgG2a, kappa
Recommended Isotype Control Rat IgG2a kappa Isotype Control (eBR2a), Biotin, eBioscience™
Class Monoclonal
Type Antibody
Clone eBioGoH3 (GoH3)
Conjugate Biotin
Form Liquid
Concentration 0.5 mg/mL
Storage Conditions 4°C, store in dark, DO NOT FREEZE!
Shipping Conditions Ambient (domestic); Wet ice (international)
RRID AB_1210591

Available Formats


Product Specific Information

The eBioGoH3 monoclonal antibody reacts with mouse and human CD49f (Integrin alpha 6), also known as VLA-6 alpha chain and platelet gpIc.
CD49f is a 120 kD transmembrane protein that associates with CD29 (integrin beta 1) to form the VLA-6 complex, and with CD104 (integrin beta 4) to form the alpha6 beta4 complex.

Expression:
Primarily on T cells, monocytes, platelets, epithelial and endothelial cells. Also found on germinal center B cells.

Cross-reactivity:
Human, mouse, and bovine integrin alpha 6.

Functional activity:
Reported to block the binding of integrin alpha 6 to laminin.

Applications Reported:
Flow cytometric analysis and immunohistology staining of frozen tissue sections.

Applications Tested:
Tested by flow cytometric analysis of human peripheral blood cells. Recommended ≤0.25 µg per test (100 µL final volume). Cell number: 10⁵–10⁸ cells/test.
Antibody should be titrated for optimal performance.

Filtration:
0.2 µm post-manufacturing filtered.


Target Information

CD49f (Integrin alpha-6, ITGA6) is the integrin alpha chain alpha 6 protein. Integrins are integral cell-surface proteins composed of alpha and beta chains that combine to form diverse integrin complexes.

  • Alpha6 + Beta4 → Integrin TSP180
  • Alpha6 + Beta1 → Integrin VLA-6

Functions:

  • Mediates cell adhesion and signaling
  • Connects extracellular matrix (ECM) to cytoskeletal linker proteins
  • Regulates cellular shape, motility, and proliferation
  • Plays a structural role in hemidesmosomes

Expression:
Predominantly in epithelial cells.

Integrin Family:

18 alpha and 8 beta subunits identified in mammals, with numerous splice variants.

Research Use:
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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