Thermo Fisher Scientific Phospho-TSC2 (Ser939) Recombinant Superclonal Antibody (23HCLC)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is predicted to react with chimpanzee, equine, and non-human primate based on sequence homology.

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They combine multiple recombinant monoclonal antibodies, providing the sensitivity of polyclonal antibodies and the specificity of monoclonal antibodies, with the consistency of recombinant production. Each lot contains a known mixture of light and heavy chains, ensuring reproducibility and eliminating biological variability associated with traditional polyclonal antibodies.

Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and performance remain unchanged.

Target Information

TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2) functions as a tumor suppressor, playing roles in vesicular transport, cell growth regulation, and transcriptional control mediated by steroid receptors. It forms a cytosolic complex with hamartin, potentially acting as a chaperone. Phosphorylation of TSC2 on Ser939 and Thr1462 regulates its interaction with hamartin and is stimulated by growth factors via the PI3K/Akt pathway. Mutations in TSC2 are associated with diseases such as lymphangioleiomyomatosis and angiomyolipoma. Alternative splicing produces multiple isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.