Thermo Fisher Scientific CD107b (LAMP-2) Recombinant Rabbit Monoclonal Antibody (SA46-01)
인간, 마우스, 랫트에서 반응하는 재조합 래빗 단클론 항체로 LAMP2(CD107b) 검출에 적합. WB, IHC, ICC/IF에 사용 가능. 높은 특이성과 민감도, 로트 간 일관성 제공. 단백질 A 정제, 1 mg/mL 농도, 4°C 또는 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SA46-01 |
| Immunogen | Synthetic peptide within Human LAMP2a aa 361-410 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809264 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.
These antibodies offer:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
LAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a lysosomal membrane protein involved in lysosome biogenesis, maintenance, and fusion with phagosomes.
It provides selectins with carbohydrate ligands and may play a role in tumor cell metastasis and lysosomal protection.
- Unmodified LAMP2: ~46 kDa
- Mature glycosylated form: 100–130 kDa
- Structure: large intra-lysosomal domain, hydrophobic transmembrane domain, short cytoplasmic tail
- Isoforms: LAMP-2A, LAMP-2B, LAMP-2C
- Used to monitor chaperone-mediated autophagy
- Deficiency causes autophagosome accumulation leading to cardiomyopathy and myopathy (Danon’s disease)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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