Thermo Fisher Scientific TSPO Recombinant Rabbit Monoclonal Antibody (SA90-03)
TSPO 단백질을 표적으로 하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체. Western blot, IHC, ICC/IF, Flow Cytometry에 적합. HEK293 발현 시스템 기반으로 높은 특이성과 일관된 품질 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400–1:1000 |
| Immunocytochemistry (ICC/IF) | 1:1000 |
| Flow Cytometry (Flow) | 1:1000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SA90-03 |
| Immunogen | Synthetic peptide within Human PBR aa 120–169 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809260 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select optimal production candidates.
Key advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
Mitochondrial peripheral-type benzodiazepine receptor (PBR), also known as TSPO, is essential in steroidogenesis, mediating cholesterol transport to the mitochondrial inner membrane upon ligand activation.
PBR consists of three subunits: an isoquinoline binding site, a voltage-dependent anion channel, and an adenine nucleotide carrier.
It is genetically conserved across species and widely expressed in peripheral organs, while in the brain it is mainly located in glial cells.
Perfluorodecanoic acid (PFDA) inhibits Leydig cell steroidogenesis by affecting PBR mRNA stability, reducing PBR expression, cholesterol transport, and steroid formation.
PRAX-1 (Peripheral Benzodiazepine Receptor-Associated Protein 1) specifically interacts with PBR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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