Thermo Fisher Scientific Dicer Monoclonal Antibody (N167/7), FITC

Thermo Fisher Scientific Dicer Monoclonal Antibody (N167/7), FITC

Applications and Tested Dilution

Species Reactivity

Human, Mouse, Rat

Host / Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

N167/7

Immunogen

Fusion protein amino acids 1638–1899 of mouse Endoribonuclease Dicer.

Conjugate

FITC

Available Formats

• Unconjugated (MA5-27595)
• APC (MA5-45568)
• PE (MA5-45571)
• PerCP (MA5-45570)
• Custom conjugation available upon request

Excitation / Emission Max

498 / 517 nm
(View spectra below)

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage Buffer

9.1 mM sodium bicarbonate/PBS, pH 7.4, with 640.91 mM DMSO, 136.36 mM ethanolamine

Contains

No preservative

Storage Conditions

4°C, store in dark

Shipping Conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2932023

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Product Specific Information

• 1 µg/mL of MA5-45569 detects Dicer in 20 µg of rat brain lysate by colorimetric immunoblot using Goat anti-mouse IgG:HRP as secondary antibody.
• Detects approximately 215 kDa.
• This antibody was formerly sold as clone S167-7.

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Target Information

Dicer is a double-stranded RNA (dsRNA) endoribonuclease central to short dsRNA-mediated post-transcriptional gene silencing. It cleaves long dsRNAs and pre-miRNAs into 21–23 nucleotide fragments with 3′ overhangs, producing siRNAs and mature miRNAs. These guide the RNA-induced silencing complex (RISC) to complementary RNAs for degradation or translation inhibition.
RNA interference mediated by siRNAs eliminates transcripts from mobile and repetitive DNA elements and degrades exogenous viral RNA. The miRNA pathway regulates specific gene expression.

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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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