Thermo Fisher Scientific NALCN Monoclonal Antibody (N187/7), APC
NALCN 단백질을 인식하는 마우스 단클론 항체로, APC 형광 표지로 세포 분석에 적합합니다. Western blot 및 면역세포염색에 검증되었으며, 사람·마우스·랫트 시료에 반응합니다. 단백질 G로 정제된 고순도 항체로 4°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N187/7 |
| Immunogen | Fusion protein amino acids 1659–1738 (cytoplasmic C-terminus) of rat NALCN |
| Conjugate | APC (Allophycocyanin) |
| Excitation/Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932026 |
Additional Formats
- Unconjugated (MA5-27593)
- FITC (MA5-45573)
- PE (MA5-45575)
- PerCP (MA5-45574)
- Custom conjugation available upon request
Product Specific Information
- 1 µg/mL of MA5-45572 detects NALCN in 20 µg of rat brain lysate by colorimetric immunoblot using Goat anti-mouse IgG:HRP as the secondary antibody.
- Detects approximately 200 kDa.
- This antibody was formerly sold as clone S187-7.
Target Information
Nalcn is a voltage-independent, cation-nonselective channel permeable to sodium, potassium, and calcium ions. It regulates the resting membrane potential and neuronal excitability. Neuropeptides such as neurotensin and substance P activate NALCN via SRC family kinase-dependent pathways. Nalcn activity is modulated by GPCRs and is essential for normal respiratory rhythm, neonatal survival, and systemic osmoregulation. It contributes to intestinal pacemaking and neuronal excitability in the substantia nigra pars reticulata (SNr).
Diseases associated with NALCN include congenital contractures of the limbs and face, hypotonia, developmental delay, and psychomotor retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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