Thermo Fisher Scientific IGF1 Monoclonal Antibody (56408)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In ELISAs, this antibody does not cross-react with recombinant mouse IGF-I, mouse IGF-II, or recombinant human IGF-II.
• Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

IGF1 (Insulin-like Growth Factor-1) is structurally and functionally related to insulin but has higher growth-promoting activity. It induces various cellular responses such as proliferation, differentiation, migration, and survival.

• Stimulates proliferation of muscle, bone, and cartilage cells
• Enhances glucose transport and glycogen/DNA synthesis at low concentrations
• Predominantly circulates bound to IGF-binding proteins (IGFBPs), which prolong its half-life
• Activates the AKT signaling pathway, promoting proliferation and inhibiting apoptosis
• Mature human IGF-I is 100% homologous with bovine and porcine IGF-I
• Low IGF1 levels are linked to Alzheimer’s disease
• Defects in the IGF1 gene cause insulin-like growth factor 1 deficiency

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.