Thermo Fisher Scientific Delta-4 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.

DELTA-4 affinity purified antibody is directed against human DELTA-4.
BLAST analysis indicates 100% homology with human DELTA-4 and ~91% homology with mouse, rat, and chimpanzee DELTA-4.
Cross-reactivity with other species has not been determined.

Target Information

Delta-like ligand 4 (DLL4), also known as Delta-4, is a transmembrane ligand for the Notch1 receptor and plays a key role in vascular development.
It is induced by VEGF and acts as a negative feedback regulator in angiogenic sprouting, promoting a differentiated vascular network.
DLL4 is strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer.
Inhibition of DLL4 leads to increased vascular proliferation but defective maturation, resulting in reduced tumor growth without apparent toxicity.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.