Thermo Fisher Scientific CYP3A4 Recombinant Rabbit Monoclonal Antibody (10B10)
Human CYP3A4 단백질을 인식하는 토끼 유래 재조합 단클론 항체. IHC 및 ELISA에 적합하며, 약물 대사 관련 연구에 활용 가능. 고순도 Affinity chromatography 정제, PBS/glycerol 완충액에 보존. 연구용 한정 제품.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 10B10 |
| Immunogen | A synthesized peptide derived from human Cytochrome P450 3A4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.18 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C or -80°C if preferred |
| Shipping conditions | Wet ice |
| RRID | AB_3092723 |
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam, and erythromycin. It also metabolizes certain steroids and carcinogens. The CYP3A4 gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously, another CYP3A gene, CYP3A3, was thought to exist; however, it is now considered a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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