Thermo Fisher Scientific CYP3A4 Recombinant Rabbit Monoclonal Antibody (10B10)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

ELISA

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam, and erythromycin. It also metabolizes certain steroids and carcinogens. The CYP3A4 gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously, another CYP3A gene, CYP3A3, was thought to exist; however, it is now considered a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.