Thermo Fisher Scientific IRAK4 Recombinant Rabbit Monoclonal Antibody (10H4)
인간 IRAK4 단백질을 인식하는 토끼 유래 재조합 단클론 항체로, Western blot, Flow cytometry, ELISA에 적합합니다. 높은 특이성과 재현성을 제공하며, HEK293 발현 시스템에서 생산된 고순도 항체입니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific IRAK4 Recombinant Rabbit Monoclonal Antibody (10H4)
Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:5,000 |
| Flow Cytometry (Flow) | 1:20–1:200 |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 10H4 |
| Immunogen | A synthesized peptide derived from human IRAK4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092476 |
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. Overexpression of IRAK-4 activates NF-kappa-B and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in the IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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