Thermo Fisher Scientific c-Myc Recombinant Rabbit Monoclonal Antibody (10F2)

Applications and Tested Dilution

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a key role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK is functionally associated with cell proliferation and regulation.
c-Myc is essential for vasculogenesis and angiogenesis during tumor development. Deregulated expression induces apoptosis in different cell types.
Antibodies against c-Myc epitopes recognize Myc-tagged proteins at either amino or carboxy termini. Amplification of c-Myc is found in lung, breast, and colon carcinomas, while N-Myc amplification occurs in neuroblastomas.
Translocation of the c-Myc locus on chromosome 8 to immunoglobulin loci on chromosomes 14, 2, or 22 is observed in Burkitt’s lymphoma and other B-cell proliferative conditions.
Aberrant c-Myc expression is reported in tumors of multiple origins, including colorectal, gastric, hepatic, mammary, ovarian, thyroidal, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.