Thermo Fisher Scientific T4S20 Polyclonal Antibody
Human T4S20 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS(40% glycerol) 완충액에 보관됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA564095
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human T4S20. Recombinant protein control fragment (Product #RP-103760) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2648174 |
Product Specific Information
Immunogen sequence:
QALLKGPLMC NSPSNSNANC EFSLKNISDI
Antigen sequence identity:
- Mouse: 63%
- Rat: 60%
Target Information
Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293).
In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293).
Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20 — this mechanism, called regulated alternative translocation (RAT), regulates the function of the transmembrane protein (PubMed:27499293).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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