Thermo Fisher Scientific TNIP2 Polyclonal Antibody
Human TNIP2 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 최적화되어 있습니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 완충액에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TNIP2. Recombinant protein control fragment (Product #RP-104131). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2648784 |
Product Specific Information
Immunogen sequence:
EDLNAKWQRY NASRDEYVRG LHAQLRGLQI PHEPELMRKE ISRLNRQLEE KINDCAEVKQ ELAASRTARD AALERVQM
Highest antigen sequence identity to the following orthologs:
- Mouse: 79%
- Rat: 82%
Target Information
TNFAIP3 (A20) is located in chromosome band 6q23, a region often deleted in B cell lymphomas. It functions as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 is a zinc-finger protein rapidly induced by TNF-α, inhibiting NF-κB-dependent gene expression and protecting cells from TNF-α cytotoxicity. Overexpression of TNFAIP3 also inhibits TLR2- and TLR4-mediated IL-8 synthesis in airway epithelial cells, acting as a negative regulator of TLR-mediated inflammatory responses and protecting the host from excessive immune reactions. At least two isoforms of TNFAIP3 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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