Thermo Fisher Scientific ALK Monoclonal Antibody (OTI1F1), TrueMAB
인간 ALK 단백질을 인식하는 마우스 모노클로날 항체로, Western Blot 및 Luminex 분석에 적합합니다. 고순도 친화 크로마토그래피로 정제되었으며 PBS/BSA/glycerol 완충액에 보관됩니다. 뇌 발달 연구 및 종양 관련 ALK 변이 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | References |
|---|---|---|
| Western Blot (WB) | 1:2,000 | - |
| Luminex (LUM) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1060–1620 of human ALK produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is essential for brain development.
Mutations, rearrangements, and amplifications in the ALK gene are associated with tumors such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangements often generate fusion genes, notably NPM-ALK, which is oncogenic.
ALK encodes a receptor tyrosine kinase with transmembrane and extracellular domains, showing high sequence similarity to LTK.
It plays a critical role in neuronal development and signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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