Thermo Fisher Scientific Phospho-Tau (Thr231) Recombinant Rabbit Monoclonal Antibody (1H6L6)

Thermo Fisher Scientific Phospho-Tau (Thr231) Recombinant Rabbit Monoclonal Antibody (1H6L6)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generates ~25 kDa light chain and ~50 kDa heavy chain bands.
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning antibody DNA sequences from immunoreactive rabbits.
• Advantages include:
  • Better specificity and sensitivity
  • Lot-to-lot consistency
  • Animal origin-free formulation
  • Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

Tau is a neuronal microtubule-associated protein predominantly found on axons. It promotes tubulin polymerization and stabilizes microtubules.

• The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, functioning as a linker between both.
• Axonal polarity is determined by Tau localization in the neuronal cell body domain defined by the centrosome.
• Short isoforms allow cytoskeletal plasticity; long isoforms contribute to stabilization.
• Hyper-phosphorylated Tau forms paired helical filaments (PHF), major components of neurofibrillary lesions in Alzheimer’s disease.
• Hyper-phosphorylation disrupts microtubule binding, leading to destabilization and neuronal degeneration.
• Kinases involved include GSK-3β, PKA, cdk5, and casein kinase II.
• Hyper-phosphorylated Tau is associated with Alzheimer’s disease, Pick’s disease, frontotemporal dementia, cortico-basal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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