Thermo Fisher Scientific CD22 Monoclonal Antibody (OTI4C3), TrueMAB
CD22 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western Blot 및 IHC(P) 등에 사용 가능. 다양한 종(Dog, Human, Mouse, Rat)에 반응하며, 높은 순도의 Lyophilized 형태로 제공. 연구용으로 B세포 관련 표지 및 백혈병·림프종 분석에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:200–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4C3 |
| Immunogen | Full length human recombinant protein of human CD22 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional round of desalting (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
CD22 (BL-CAM) is a type I integral membrane glycoprotein (130–140 kDa) expressed in cytoplasm and membrane of B-lymphocytes.
It appears early in B-cell differentiation along with CD19 and is mainly expressed in mature B cells (CD22+) but absent in plasma cells (CD22−).
CD22 is strongly expressed in hairy cell leukemia and positive in diffuse large B-cell lymphoma and nodular lymphocyte predominance Hodgkin’s lymphoma, but negative in classical Hodgkin’s lymphoma.
It binds preferentially to α2,6-linked sialic acid and plays a role in regulation of B-cell receptor signaling through phosphorylation and interaction with Src family kinases and phosphatases.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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